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B L T Companies is a Yuma, AZ-based company in the Business Services sector.
TIXiMED, Inc. is focused on developing and commercializing TXNIP inhibiting medication as a first-of-its-kind oral therapeutic for Type 1 and Type 2 diabetes. TIXiMED is the exclusive license holder for the patent (composition of matter and method of use) surrounding TIX100, a novel small molecule that normalizes pancreatic beta cell TXNIP, a detrimental protein elevated in Type 1 and Type 2 diabetes. Increased TXNIP causes pancreatic islet dysfunction and death of insulin-producing beta cells and thereby contributes to the development and progression of diabetes. Diabetes affects more than half a billion people worldwide. Those affected by Type 1 diabetes are dependent on multiple daily insulin injections or continuous insulin infusions to stay alive and manage their blood sugar. Oral anti-diabetic drugs are only approved for Type 2 diabetes, but can be associated with multiple side effects, underlining the need for novel and better oral diabetes medications for Type 1 and Type 2 diabetes. TXNIP inhibition has recently been demonstrated to be an effective and safe therapeutic approach in adults and children with recent onset Type 1 diabetes and TIX100 shows beneficial, anti-diabetic effects in 4 different mouse models. Advantages of TIX100 include oral availability, no associated hypoglycemia or weight gain, potent inhibition of detrimental TXNIP in human islets, and a favorable pharmacokinetic and safety profile. In addition, TIX100 inhibits excessive glucagon secretion and hepatic glucose production and protects against fatty liver. Thus, TIX100 holds promise for durable, weight-neutral improvement in glycemic control in Type 1 and Type 2 diabetes by targeting common underlying pathology and promoting patients own islet cell health.
Hinshaw and Culbertson is a full-service national law firm providing coordinated legal services across the United States, as well as regionally and locally. Hinshaw lawyers represent businesses, governmental entities and individuals in complex litigation, regulatory and transactional matters. Founded in 1934, the firm has 525 attorneys in offices located in Arizona, California, Florida, Illinois, Indiana, Massachusetts, Minnesota, Missouri, New York, Rhode Island, Wisconsin and London.
The government of Illinois, under the Constitution of Illinois, has three branches of government: executive, legislative and judicial. The executive branch is split into several statewide elected offices, with the Governor as chief executive, and has numerous departments, agencies, boards and commissions. Legislative functions are granted to the General Assembly, composed of the 118-member House of Representatives and the 59-member Senate. The judiciary is composed of the Supreme Court and lower courts. The government of Illinois has numerous departments, agencies, boards and commissions, but the code departments, so called because theyre established by the Civil Administrative Code of Illinois, provide most of the states services: Department on Aging Department of Agriculture Department of Central Management Services Department of Children and Family Services Department of Commerce and Economic Opportunity Department of Corrections Department of Employment Security Department of Financial and Professional Regulation Department of Healthcare and Family Services Department of Human Rights Department of Human Services Department of Juvenile Justice Department of Labor Department of the Lottery Department of Natural Resources Department of Public Health Department of Revenue Department of State Police Department of Transportation Department of Veterans Affairs
Castle Creek Arbitrage, Llc is a Chicago, IL-based company in the Business Services sector.